We have upgraded to Windows 10 without major problems. Scanbox along with all the other drivers appear to be running just fine. The only issue that we ran into is access to the parallel computing toolbox using a GeForce GTX Titan Z card. While Scanbox can still run without the parallel computing toolbox, some features will be disabled, such as online segmentation.
So go ahead and happy upgrading!
Update: The GeForce GTX Titan Z card works after all, but you need to adjust the settings in the nVidia control panel to allow Matlab exclusive access to one of the nodes. Drop me an email if you run into such a problem.